Informatics Publishing Limited

K. Selvaraju ¹, K. Vengadesh Prabhu ², K. Karthick ², J. Padma Preetha ², K. S. G. Arul Kumaran ²

Affiliations
1 Department of Pharmaceutics, KMCH College of Pharmacy, Coimbatore-641048, Tamilnadu, IN
2 KMCH College of Pharmacy, Coimbatore-641048, Tamilnadu, IN

Abstract

Various Colloidal vesicular system employed in controlled and targeted delivery system are liposomes, Niosomes, Virosomes, Immuuoliposomes, Transferosomes and Pharmacosomes. Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids and may exist as ultrafine vesicular, micellar or hexagonal aggregates, depending on the chemical structure. Because the system is formed by linking a drug (pharmakon) to a carrier (soma) they are called pharmacosomes. They are amphiphilic lipid vesicular systems that have shown their potential in improving the bioavailability of poorly water soluble as well as poorly lipophilic drugs. They are bearing unique advantages over liposomes and niosomes vesicles that can pass through biomembranes efficiently. They potentially delivery the drugs directly to the site of infection, leading to reduction of drug toxicity with no adverse effect.

Keywords

Pharmacosomes, Amphiphilic, Controlled and Targeted Drug Delivery System.

Full Text

     

K. Selvaraju ¹, K. S. G. Arulkumaran ², K. Karthick ², K. Vengadesh Prabhu ², J. Padma Preetha ², R. Arrivukkarasu ²

Affiliations
1 Department of Pharmaceutics, KMCH College of Pharmacy, Coimbatore-641 048, Tamil Nadu, IN
2 KMCH College of Pharmacy, Coimbatore-48, Tamil Nadu, IN

Abstract

The term "Phyto" means plant while "some" means cell-like. Phytosome are little cell like structure. This is an advanced herbal delivery system which contains the bioactive phytoconstituents of herb extract surrounds and bound by Phospholipids. The potential uses of large number of herbal drugs are limited due to their poor absorption and poor bioavailability after oral administration. Phytosomes exhibit better pharmacokinetic and pharmacodynamic profile than conventional herbal extracts. Phytosome technology has been effectively used to enhanced the bioavailability of many popular herbal extracts including milk thistle, ginkgo biloba, grape seed, green tea, hawthorn, ginseng etc, and can be developed for various therapeutic uses or dietary suppliments. The phospholipid molecular structure includes a water soluble head and two fat soluble tails, because of this dual solubility the phospholipid acts as an effective emulsifier which is also one of the chief components of the membranes in our cells.

Keywords

Phytosomes, Phospholipids, Herbal Extracts, Bioavailability.

Full Text